Peri-conception maternal lipid profiles predict pregnancy outcomes

详细信息    查看全文

• 作者：Enitan Ogundipe^a ; Mark R. Johnson^b ; Yiqun Wang^c ; Michael A. Crawford^b ; ^{michael.crawford@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AA ; Arachidonic acid ; DHA ; Docosahexaenoic acid ; ROC ; Receiver operating characteristic ; EFA ; Essential fatty acids ; ALSPAC ; The Avon Longitudinal Study of Parents and Children ; EPA ; Eicosapentaenoic acid ; GDM ; Gestational diabetes mellitus ; PET ; Pre-eclamptic toxaemia ; LBW ; Low birth weight ; HIV ; Human immunodeficiency virus ; NHC ; Normal healthy controls ; GLA ; Gamma-linolenic acid ; BHT ; Butylated hydroxytoluene ; FAME ; Fatty acid methyl esters ; AUC ; Area under the curve ; MUFA ; Mono-unsaturated f
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：114
• 期：Complete
• 页码：35-43
• 全文大小：769 K

文摘

In this study, healthy women and those at high-risk of adverse pregnancy outcomes (pre-eclampsia, fetal growth restriction, gestational diabetes) were selected to assess the effect of fatty acid supplementation. The purpose of this paper is to report two novel findings (i) at recruitment the receiver operating characteristic (ROC) for erythrocyte oleic acid predicted spontaneous delivery at 34 weeks gestation (ROC=0.926 n=296) for all women entering the study. Further analysis revealed oleic and all monounsaturated fatty acids were similarly predictive with or without a supplement during the pregnancy. (ii) At delivery, we observed a biomagnification of saturated fatty acids from mother to fetus with the reverse for monounsaturates. The major conclusions are (i) the status of the mother in the months prior to conception is a stronger predictor of preterm delivery than the events during the pregnancy. (ii) Saturated fats may be playing an important function in supporting fetal membrane growth.