The delicate balance of macrophages in colorectal cancer; their role in tumour development and therapeutic potential
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- 作者：R. Brastera ; 1 ; M. Bö ; gelsa ; 1 ; R.H.J. Beelena ; M. van Egmonda ; b ; m.vanegmond@vumc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADCC ; antibody dependent cellular cytotoxicity ; ADCP ; antibody-dependent cellular phagocytosis ; BCG ; bacillus calmette-gué ; rin ; CDC ; complement-dependent cytotoxicity ; CSF-1 ; colony stimulating factor 1 ; CTL ; cytotoxic T lymphocyte ; EGFR ; epithelial growth factor receptor ; FcγR ; IgG Fc receptor ; GM-CSF ; granulocytic-macrophage colony stimulating factor ; HLA-DR ; human leukocyte antigen DR ; HRG ; histidine-rich glycoprotein ; IFN-γ ; interferon-γ ; IgG ; immunoglobulin G ; IL-12 ; interleukin 12 ; L
- 刊名：Immunobiology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：222
- 期：1
- 页码：21-30
- 全文大小：1324 K
文摘
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Macrophages are present in high amounts in various types of cancer.
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Macrophages are potent modulators of the tumour micro-environment.
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Monoclonal antibody therapy in combination with macrophage activation is a promising therapy.
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