Integrative proteomic and microRNA analysis of the priming phase during rat liver regeneration
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- 作者：Xiaofang Genga ; b ; Cuifang Changa ; b ; c ; Xiayan Zanga ; b ; c ; Jingyan Suna ; b ; c ; Pengfei Lia ; b ; c ; Jianli Guoa ; b ; c ; Cunshuan Xua ; b ; c ; cellkeylab@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miRNAs ; microRNAs ; 3&prime ; UTRs ; 3&prime ; untranslated regions ; PH ; partial hepatectomy ; LR ; liver regeneration ; iTRAQ ; isobaric tags for relative and absolute quantitation ; IPA ; ingenuity pathway analysis ; SCX ; strong cation exchange ; HCC ; hepatocellular carcinoma ; VEGF ; vascular endothelial growth factor ; CLIC4 ; chloride intracellular channel 4 ; PDCD6 ; programmed cell death 6 ; DAP1 ; death-associated protein 1 ; mTOR ; mammalian target of rapamycin ; AMPK ; AMP-activated protein kinase ; SIRT5 ; NAD-
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：224-232
- 全文大小：1173 K
文摘
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High-throughput sequencing of miRNA expression profiles in rat LR was performed.
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iTRAQ-based proteomics analysis of the priming phase of rat LR was conducted.
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6 miRNAs were found to regulate the priming phase of rat LR by integrative analysis.
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A functional molecular network was built in the priming phase of rat LR.
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