Women with endometriosis have higher comorbidities: Analysis of domestic data in Taiwan

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• 作者：Sen-Wen Teng^a ; ^b ; Huann-Cheng Horng^c ; ^d ; Chi-Hong Ho^c ; ^d ; Ming-Shyen Yen^c ; ^d ; Hsiang-Tai Chao^c ; ^d ; Peng-Hui Wang^c ; ^d ; ^e ; ^{phwang@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author} ; ^{phwang@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; ^{pongpongwang@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; The Taiwan Association of Gynecology Systematic Review Group^** ; Yen-Hou Chang^g ; Yi Chang^g ; Kuan-Chong Chao^g ; Yi-Jen Chen^g ; Chi-Mu Chuang^g ; Chen-Yu Huang^g ; Ling-Yu Jiang^g ; Hsin-Yang Li^g ; Chia-Hao Liu^g ; Pi-Lin Sun^g ; Kuo-Chang Wen^g ; Hua-Hsi Wu^g ; Hann-Chin Yu^g ; Fong-Yuan Ju^h ; Chih-Ping Tsaiⁱ ; Wen-Hsun Chang^g ; ^j ; Yen-Mei Hsu^g ; ^j ; Shu-Yun Huang^g ; ^j ; Na-Rong Lee^g ; ^j ; Chih-Yao Chen^k ; Ting-Chen Chang^l ; Wen-Chun Chang^l ; Chii-Hou Chen^l ; Ruey-Jian Chen^l ; Song-Nan Chow^l ; Yih-Ron Lien^l ; Bor-Ching Sheu^l ; Pao-Ling Torng^l ; Men-Luh Yen^l ; Wen-Ling Lee^m ; ⁿ ; Kuan-Chin Wangⁿ ; Chih-Long Chang^o ; Chih-Ping Chen^o ; Jen-Ruei Chen^o ; Tze-Chien Chen^o ; Jian-Pei Huang^o ; Ming-Chao Huang^o ; Yeou-Lih Wang^o ; Cheng-Chang Chang^p ; Jah-Yao Liu^p ; Her-Young Su^p ; Yu-Chi Wang^p ; Mu-Hsien Yu^p ; Ching-Chuang Chu^q ; Lee-Wen Huang^q ; Kok-Min Seow^q ; Tsung-Hsuan Lai^r ; Fa-Kung Lee^r ; Ching-Hui Chen^s ; Wei-Min Liu^s ; Jyh-Shin Chiou^t ; Ben-Shian Huang^t ; Yen-Feng Lu^t ; Sheng-Mou Hsiao^u ; Hsu-Dong Sun^u ; Wen-Yih Wu^u ; Kuo-Hu Chen^v ; Jeng-Hsiu Hung^v ; Hung-Cheng Lai^w ; Chiou-Chung Yuan^w ; Ching-Hung Hsieh^x ; Chin-Jung Wang^y ; Chia-Hao Chan^z ; Shing-Jyh Chang^z ; Chuan-Chi Shih^z ; Man-Jung Hung^aa ; Shih-Tien Hsu^ab ; Yu-Min Ke^ab ; Chien-Hsing Lu^ab ; Lou Sun^ab ; Wei-Chun Chang^ac ; Yao-Ching Hung^ac ; Wu-Chou Lin^ac ; Po-Hui Wang^ad ; Tze-Ho Chen^ae ; Yiu-Tai Li^af ; Meng-Hsing Wu^ag ; Kuo-Feng Huang^ah ; Fei-Chi Chuang^ai ; ^aj ; Hung-Chun Fu^ai ; ^aj ; Fu-Tsai Kung^ai ; ^aj ; Kuan-Hui Huang^ai ; ^aj ; San-Nung Chen^ak ; An-Jen Chiang^ak ; Ju-Yueh Li^ak ; Li-Te Lin^ak ; Hsiao-Wen Tsai^ak ; Kuan-Hao Tsui^ak
• 关键词：comorbidity ; endometriosis ; Taiwan
• 刊名：Journal of the Chinese Medical Association
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：79
• 期：11
• 页码：577-582
• 全文大小：247 K

文摘

Endometriosis, defined by the presence of viable extrauterine endometrial glands and stroma, can grow or bleed cyclically, and possesses characteristics including a destructive, invasive, and metastatic nature. Since endometriosis may result in pelvic inflammation, adhesion, chronic pain, and infertility, and can progress to biologically malignant tumors, it is a long-term major health issue in women of reproductive age. In this review, we analyze the Taiwan domestic research addressing associations between endometriosis and other diseases. Concerning malignant tumors, we identified four studies on the links between endometriosis and ovarian cancer, one on breast cancer, two on endometrial cancer, one on colorectal cancer, and one on other malignancies, as well as one on associations between endometriosis and irritable bowel syndrome, one on links with migraine headache, three on links with pelvic inflammatory diseases, four on links with infertility, four on links with obesity, four on links with chronic liver disease, four on links with rheumatoid arthritis, four on links with chronic renal disease, five on links with diabetes mellitus, and five on links with cardiovascular diseases (hypertension, hyperlipidemia, etc.). The data available to date support that women with endometriosis might be at risk of some chronic illnesses and certain malignancies, although we consider the evidence for some comorbidities to be of low quality, for example, the association between colon cancer and adenomyosis/endometriosis. We still believe that the risk of comorbidity might be higher in women with endometriosis than that we supposed before. More research is needed to determine whether women with endometriosis are really at risk of these comorbidities.