Role of p21^WAF1 and p27^KIP1 in Predicting Biochemical Recurrence for Organ-confined Prostate Adenocarcinoma

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• 作者：Tony Tong-Lin Wu ; Jyh-Seng Wang ; Bang-Ping Jiaan ; Chia-Cheng Yu ; Jeng-Yu Tsai ; Jen-Tai Lin ; Jong-Khing Huang
• 关键词：p21 ; p27 ; prognosis ; prostate neoplasms
• 刊名：Journal of the Chinese Medical Association
• 出版年：2007
• 出版时间：January 2007
• 年：2007
• 卷：70
• 期：1
• 页码：11-15
• 全文大小：276 K

文摘

Background

Both p21^WAF1 and p27^KIP1 have been reported as prognostic markers predicting biochemical failure for prostate cancers. We examined the expression and prognostic significance of p21^WAF1 and p27^KIP1 in organ-confined (pT2) prostate cancer patients.

Methods

The medical records of 53 pT2 prostate adenocarcinomas were analyzed retrospectively. Radical prostatectomy specimens were stained using anti-p21^WAF1 and anti-p27^KIP1 antibodies. Biochemical relapse was defined as 2 consecutive elevations in serum prostate specific antigen (PSA) level > 0.2 ng/mL with an interval of more than 3 months. The prognostic significance of p21^WAF1 and p27^KIP1 expression was assessed.

Results

p21^WAF1 immunoreactivity was found in 19 patients (35.8 % ). Twenty-nine tumors (54.7 % ) had decreased p27^KIP1 expression. Both markers were not associated with Gleason scores (p = 1.00 for both). At a median follow-up of 49 months, 15 patients (28.3 % ) experienced biochemical recurrence. Both p21 and p27 had no prognostic significance in log-rank test (p = 0.98 and p = 0.64, respectively).

Conclusion

p21^WAF1 and p27^KIP1 expression have no role in predicting biochemical relapse for stage pT2 prostate cancers.