Copper-catalyzed synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles via [3+2] cycloadditions of hydrazones and nitroolefins

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• 作者：Chong Shi ; Chaowei Ma ; Haojie Ma ; Xiaoqiang Zhou ; Jinhui Cao ; Yuxing Fan ; Guosheng Huang ; ^{hgs@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pyrazoles ; Copper-catalyzed ; Regioselectivity ; Cycloaddition
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：7 July 2016
• 年：2016
• 卷：72
• 期：27-28
• 页码：4055-4058
• 全文大小：579 K

文摘

A highly economical and efficient copper(I)-catalyzed regioselective method for the synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles via [3+2] cycloaddition of hydrazones and nitroolefins has been reported. This process displays excellent applicability with a wide range of substrates under mild conditions.