Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells
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- 作者：Anning Yanga ; d ; 1 ; Huiping Zhangb ; c ; 1 ; Yue Suna ; e ; Yanhua Wangb ; Xiaoming Yanga ; c ; Xiaoling Yanga ; c ; Hui Zhanga ; Wei Guoa ; Guangrong Zhua ; Jue Tiana ; c ; Yuexia Jiaa ; c ; Yideng Jianga ; c ; nyxxgjyd@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Preeclampsia ; miR-148a/152 ; DNMT1 ; FABP4 ; DNA methylation
- 刊名：Placenta
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：49-62
- 全文大小：3893 K
文摘
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FABP4 and miR-148a/152 were upregulated and DNMT1 was downregulated in placentae of pregnant rats and HTR-8 cells.
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DNMT1 overexpression increased FABP4 DNA methylation and decreased its expression in HTR-8 cells.
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DNMT1 is a direct target of miR-148a/152.
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miR-148a/152 caused FABP4 hypomethylation by targeting DNMT1 in preeclampsia.
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FABP4 is a potential therapeutic target for preeclampsia.
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