Label-free quantitative proteomics reveals differentially expressed proteins in high risk childhood acute lymphoblastic leukemia
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- 作者：Gang Xua ; Zhijie Lib ; Lili Wangb ; Fang Chenc ; Zuofei Chia ; Min Gua ; Shuang lia ; Di Wub ; Jianing Miaob ; Yi Zhangb ; Liangchun Haoa ; Yang Fanb ; fanyang1973@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acute lymphoblastic leukemia ; Risk stratification ; Label free ; LC-MS/MS ; Proteomics
- 刊名：Journal of Proteomics
- 出版年：2017
- 出版时间：6 January 2017
- 年：2017
- 卷：150
- 期：Complete
- 页码：1-8
- 全文大小：706 K
文摘
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We present a comparative proteomics of high risk and low risk children ALL.
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86 differentially expressed proteins were identified.
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Protein alterations reflected the changes in pre-mRNA splicing, DNA damage response, and stress response.
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Our result provided new information for risk stratification of B-ALL and might be valuable to find new therapeutic targets.
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