Lysine acetylation and cancer: A proteomics perspective
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- 作者：Jeovanis Gil ; jeovanis@ccg.unam.mx" class="auth_mail" title="E-mail the corresponding author ; Alberto Ramí ; rez-Torres ; Sergio Encarnació ; n-Guevara ; encarnac@ccg.unam.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lysine acetylation ; Lysine acetyltransferases ; Lysine deacetylases ; Bromodomains ; Cancer ; Proteomics ; Stoichiometry
- 刊名：Journal of Proteomics
- 出版年：2017
- 出版时间：6 January 2017
- 年：2017
- 卷：150
- 期：Complete
- 页码：297-309
- 全文大小：1290 K
文摘
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Enzymes and proteins involved in lysine acetylation are deregulated in cancer.
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KATs KDACs and bromodomain proteins may act as oncoproteins or tumor suppressors.
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A strategy for in depth characterization of lysine acetylation is proposed.
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Stoichiometry of acetylation can be determined by isotopic labeling and MS analysis.
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