An early dysregulation of FAK and MEK/ERK signaling pathways precedes the β-amyloid deposition in the olfactory bulb of APP/PS1 mouse model of Alzheimer's disease
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- 作者：Mercedes Laché ; n-Montesa ; 1 ; Andrea Gonzá ; lez-Moralesa ; 1 ; Xabier Martí ; nez de Morentinb ; Estela Pé ; rez-Valderramab ; Karina Ausí ; nb ; Marí ; a Victoria Zelayaa ; Antonio Sernac ; Ester Asod ; Isidro Ferrerd ; Joaquí ; n Ferná ; ndez-Irigoyena ; b ; 2 ; Enrique Santamarí ; aa ; b ; 2 ; esantamma@navarra.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; APP ; amyloid precursor protein ; BAD ; Bcl2-associated agonist of cell death ; Camk2a ; Ca2 ; +/CaM-dependent protein kinase type II subunit alpha ; ERK ; extracellular signal-regulated kinase ; FAK ; focal adhesion kinase ; Gdap1 ; ganglioside-induced differentiation-associated protein 1 ; MARCKS ; Myristoylated alanine-rich C kinase substrate ; MEK ; Dual specificity mitogen-activated protein kinase kinase ; Ndufs2 ; NADH dehydrogenase iron-sulfur protein 2 ; OB ; olfactory bulb ; PAR
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：149-158
- 全文大小：1061 K
文摘
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The OB proteomic profile derived from APP/PS1 mice was studied using a label-free LC/MS-MS approach
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25 olfactory proteins were deregulated in APP/PS1 mice.
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APP/PS1 mice and human AD present an opposite activation pattern in specific olfactory survival routes.
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