Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis

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• 作者：Hai-Xia GE^a ; ^b ; Jian ZHANG^b ; ^# ; Kun QIAN^a ; Bo-Yang YU^c ; ^{boyangyu59@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-Ping CHEN^d
• 关键词：THPBs library ; Diversity synthesis ; Microbial glycosylation ; Chemical demethylation
• 刊名：Chinese Journal of Natural Medicines
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：14
• 期：10
• 页码：783-788
• 全文大小：1214 K

文摘

The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines (THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentatively identified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.