Glutamate excitotoxicity and Ca2+-regulation of respiration: Role of the Ca2+ activated mitochondrial transporters (CaMCs)
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- 作者：Carlos B. Ruedaa ; b ; c ; 1 ; Irene Llorente-Folcha ; b ; c ; 2 ; Javier Trabad ; Ignacio Amigoe ; Paloma Gonzalez-Sancheza ; b ; c ; Laura Contrerasa ; b ; c ; Iné ; s Juaristia ; b ; c ; Paula Martinez-Valeroa ; b ; c ; Beatriz Pardoa ; b ; c ; Araceli del Arcoa ; b ; c ; f ; Jorgina Satrusteguia ; b ; c ;
- 关键词：ATP-Mg/Pi carrier ; Aspartate/glutamate carrier ; Aralar ; Calcium ; Excitotoxicity ; Mitochondria ; PARP-1 ; SCaMC-3
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1857
- 期：8
- 页码：1158-1166
- 全文大小：1097 K
文摘
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Glutamate stimulates respiration by enhancing ATP demand and by Ca2+ signaling.
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Ca2+ activated Aralar and SCaMC-3 are necessary for glutamate-stimulation of respiration.
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Excitotoxic PARP-1 activation causes mitochondrial ATP depletion, counteracted by SCaMC-3.
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Adenine nucleotide uptake by SCaMC-3 prevents excitotoxic mitochondrial permeability transition.
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Aralar and SCaMC-3 protect in vivo against kainate induced toxicity.
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