Cyanidin 3-O-β-glucopyranoside activates peroxisome proliferator-activated receptor-γ and alleviates cognitive impairment in the APPswe/PS1ΔE9 mouse model
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- 作者：Nan Song ; Ling Zhang ; Wei Chen ; Hua Zhu ; Wei Deng ; Yunlin Han ; Jianguo Guo ; Chuan Qin ; qinchuan@pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; Cy3G ; cyanidin 3-O-β-glucopyranoside ; Aβ25&ndash ; 35 ; beta-amyloid 25&ndash ; 35 ; PAP mouse ; APPswe/PS1ΔE9 mouse ; PPARγ ; peroxisome proliferator-activated receptor-γ ; SPs ; senile plaques ; H2O2 ; hydrogen peroxide ; CNS ; central nervous system ; HepG2 cells ; human liver hepatocellular carcinoma cell line ; IR ; insulin resistance ; SH-SY5Y cells ; a human neuroblastoma cell line ; DMEM ; Dulbecco's Modified Eagle's Medium ; DMSO ; dimethyl sulfoxide ; MTT ; 3-(4 ; 5-dimethyl-2-thiazolyl)-2
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1862
- 期：9
- 页码：1786-1800
- 全文大小：2792 K
文摘
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Cy3G neutralizes the cytotoxicity and prevents SH-SY5Y cells injury induced by Aβ25-35 and activates PPARγ expression.
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Cy3G inhibited the aggregation and membrane binding of Aβ25-35 at the molecular level.
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Treatment with Cy3G improved behaviors and cerebral glucose metabolism in PAP mice.
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Cy3G may be a potential PPARγ agonist and bring an important light in the field of Alzheimer's disease intervention.
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