Generation of cardiac pacemaker cells by programming and differentiation
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- 作者：Britta Husse ; britta.husse@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Wolfgang-Michael Franz wolfgang-michael.franz@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pacemaker cells ; Membrane-clock ; Ca2 ; +-clock ; Tbx3 ; Pluripotent stem cells ; Programming and differentiation
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1863
- 期：7
- 页码：1948-1952
- 全文大小：636 K
文摘
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Differentiation of Tbx3-Myh6 double transgenic embryonic stem cells leads to functioning cardiac pacemaker cells.
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Pacemaker cells are characterized by electrophysiological features, Ca2 + -handling and ability to stimulate adult myocardium.
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Generated cardiac pacemaker cells are an excellent testing model for new antiarrhythmics.
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More studies are required before the generated cardiac pacemaker cells can be used in the cell therapy.
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