MD-1 deficiency attenuates dextran sodium sulfate (DSS)-induced colitis through modulating the function of colonic lamina propria dendritic cells
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- 作者：Huaqin Pana ; b ; 1 ; phq2012@whu.edu.cnv" class="auth_mail" title="E-mail the corresponding author ; panhuaqin2004@sina.com" class="auth_mail" title="E-mail the corresponding author ; Guqin Zhangc ; 1 ; zgqxiaoxiao@126.com" class="auth_mail" title="E-mail the corresponding author ; Lin Zhanga ; b ; zhanglin19910528@163.com" class="auth_mail" title="E-mail the corresponding author ; Wei Wanga ; b ; weiwang0303@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jian Shanga ; b ; shangjian1988@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiaobing Wanga ; b ; wxbandzhp@163.com" class="auth_mail" title="E-mail the corresponding author ; Qiu Zhaoa ; b ; zhaoqiu@medmail.com.cn" class="auth_mail" title="E-mail the corresponding author ; Jin Lia ; b ; lijinluyi@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MD-1 ; Colitis ; Dendritic cells ; Dextran sodium sulfate
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：1-10
- 全文大小：2923 K
文摘
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Elevated MD-1 mRNA is found in the colon of IBD patients and diseased mice.
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MD-1−/− mice are protected against DSS-induced colitis characterized by decreased colonic inflammatory gene expression and infiltration of colonic inflammatory cells.
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MD-1−/− mice do not alter intestinal permeability after DSS treatment.
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MD-1 deficiency modulates the function of colonic lamina propria DCs (LPDCs).
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