miR-451 suppresses the NF-kappaB-mediated proinflammatory molecules expression through inhibiting LMP7 in diabetic nephropathy
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- 作者：Yan Suna ; Rui Pengb ; Huimin Pengc ; Handeng Liuc ; Li Wena ; Tianhui Wua ; Hong Yia ; Ailing Lia ; Zheng Zhanga ; zhangzheng92@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MiR-451 ; LMP7 ; NF- κB ; Inflammation ; Diabetic nephropathy
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：433
- 期：Complete
- 页码：75-86
- 全文大小：3033 K
文摘
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miR-451 was knockdown and LMP7 was overexpression in kidneys of db/db DN mice and high glucose cultured MCs.
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miR-451 directly inhibited LMP7 to decrease NF-κB-mediated inflammation in H-MC and in the kidneys of db/db DN mice.
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overexpression of miR-451 attenuated glomerular damage in db/db mice.
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