Nongenomic and genomic effects of 1¦Á,25(OH)₂ vitamin D₃ in rat testis

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• 作者：Leila Zanatta^a ; ^b ; Ariane Zamoner^a ; Ana Paula Zanatta^a ; Hé ; lè ; ne Bouraï ; ma-Lelong^b ; Christelle Delalande^b ; Camille Bois^b ; Serge Carreau^b ; Fá ; tima Regina Mena Barreto Silva^a ; ^{mena@mbox1.ufsc.br}
• 关键词：1¦Á ; 25(OH)2 vitamin D3 ; VDR ; Testis ; Sertoli cells ; Ionic channels
• 刊名：Life Sciences
• 出版年：2011
• 出版时间：10 October, 2011
• 年：2011
• 卷：89
• 期：15-16
• 页码：515-523
• 全文大小：1K

文摘

The steroid hormone 1¦Á,25(OH)₂-vitamin D₃ (1,25D₃) regulates gene transcription through a nuclear receptor (VDRnuc) and initiation of rapid cellular responses through a putative plasma membrane-associated receptor (VDRmem). It has been described that successful mating and fertility rates are significantly decreased in vitamin D deficient male rats and a VDR null mutant rodent has decreased sperm count and motility and expresses rare spermatogenesis. Although the Sertoli cells are pointed as the major target of 1,25D₃ in the testis the mechanism of 1,25D₃ action, particularly in Sertoli cells, remains unclear. Several studies undertaken in the testicular cells showed that 1,25D₃ can produce both genomic and nongenotropic actions in those cells. 1,25D₃ can modulate kinase activities and ionic fluxes (Ca²⁺ and Cl^{?/sup>) at the plasma membrane resulting in the regulation of secretory processes in Sertoli cells. The enormous complexity of the nongenomic actions of 1,25D₃ implies that specific receptor or specific ligand-binding sites located on the plasma membrane or in the nucleus are believed to initiate specific cell responses. Apparently the choice of the signaling pathways to be activated after the interaction of the hormone with cell surface receptors is directly related with the physiological action to be better accomplished. The demonstration that 1,25D₃ can regulate both Sertoli cell and sperm function may be useful for the study and development of new therapeutic strategies to the treatment of male reproductive disorders. This review summarizes recent research on the rapid actions of 1,25D₃ and identifies questions that remain to be answered in this area.}