Phytoconstituents from Vitex agnus-castus fruits

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• 作者：Shao-Nong Chen^a ; J. Brent Friesen^b ; Donna Webster^a ; ^c ; ¹ ; Dejan Nikolic^a ; Richard B. van Breemen^a ; Z. Jim Wang^c ; Harry H.S. Fong^a ; Norman R. Farnsworth^a ; Guido F. Pauli^a ; ^{gfp@uic.edu"" rel=""nofollow}
• 关键词：Vitex agnus-castus ; Labdane diterpene ; Viteagnusin I ; Flavonoids ; Opioid activity
• 刊名：Fitoterapia
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：82
• 期：4
• 页码：528-533
• 全文大小：347 K

文摘

A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding.