A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
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- 作者：Konstantinos Tzelepis1 ; 7 ; Hiroko Koike-Yusa1 ; 7 ; Etienne De Braekeleer1 ; Yilong Li1 ; Emmanouil Metzakopian1 ; Oliver M. Dovey1 ; Annalisa Mupo1 ; Vera Grinkevich1 ; Meng Li1 ; Milena Mazan1 ; Malgorzata Gozdecka1 ; Shuhei Ohnishi1 ; Jonathan Cooper1 ; Miten Patel1 ; Thomas McKerrell1 ; Bin Chen1 ; Ana Filipa Domingues3 ; Paolo Gallipoli4 ; 5 ; Sarah Teichmann1 ; Hannes Ponstingl1 ; Ultan McDermott1 ; Julio Saez-Rodriguez2 ; 6 ; Brian J.P. Huntly4 ; 5 ; Francesco Iorio2 ; Cristina Pina3 ; cp533@medschl.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; George S. Vassiliou1 ; 4 ; 5 ; gsv20@sanger.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Kosuke Yusa1 ; 8 ; ky1@sanger.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：CRISPR ; genetic screen ; genetic vulnerability ; acute myeloid leukemia ; AML ; KAT2A ; MB-3
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：1193-1205
- 全文大小：3710 K
文摘
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Optimized CRISPR platform for identification of genome-wide genetic vulnerabilities
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Catalog of genetic vulnerabilities in acute myeloid leukemia cell lines
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KAT2A inhibition induces myeloid differentiation and apoptosis
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KAT2A inhibition arrests the growth of primary AML cells, but not of normal progenitors
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