Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array
详细信息 查看全文
- 作者：Moran G. Goren1 ; 3 ; Shany Doron2 ; 3 ; Rea Globus1 ; Gil Amitai2 ; Rotem Sorek2 ; rotem.sorek@weizmann.ac.il" class="auth_mail" title="E-mail the corresponding author ; Udi Qimron1 ; 4 ; ehudq@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：adaptation ; spacer integration ; elongated repeat ; shortened repeat ; anchor site
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：16
- 期：11
- 页码：2811-2818
- 全文大小：1680 K
文摘
- •
Inverted repeats in the type I-E CRISPR-Cas system are essential for adaptation
- •
Each inverted repeat encodes a motif serving as an anchor site for a molecular ruler
- •
These molecular rulers determine the spacer insertion site regardless of the sequence
- •
The findings support a model considering all known steps in spacer adaptation
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |