Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity
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- 作者：Sabina Sangaletti1 ; 4 ; sabina.sangaletti@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Claudio Tripodo2 ; Alessandra Santangelo1 ; Nadia Castioni1 ; Paola Portararo1 ; Alessandro Gulino2 ; Laura Botti1 ; Mariella Parenza1 ; Barbara Cappetti1 ; Rosaria Orlandi3 ; Elda Tagliabue3 ; Claudia Chiodoni1 ; Mario P. Colombo1 ; mariopaolo.colombo@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer ; epithelial to mesenchymal transition ; EMT ; extracellular matrix ; ECM ; myeloid-derived suppressor cells ; MDSC ; SPARC ; aminobisphosphonates ; cyclooxygenase-2 ; COX-2 ; granulocyte-macrophage colony-stimulating factor ; GM-CSF ; granulocyte colony-stimulating factor ; G-CSF ; CXCL12
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：27 September 2016
- 年：2016
- 卷：17
- 期：1
- 页码：233-248
- 全文大小：11160 K
文摘
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In breast cancer, the extracellular matrix can impact the immune microenvironment
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Suppressive activity of myeloid cells is required for EMT of breast cancer cells
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Interrupting ECM-MDSCs crosstalk can revert EMT and restore chemosensitivity
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