Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4

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• 作者：Yibin Zhuang^† ; ; ^a ; Xiancun Teng^† ; ; ^a ; Yi Wang^a ; Peipei Liu^a ; Hui Wang^a ; Jing Li^a ; Guoqiang Li^a ; Weiming Zhu ; ^a ; ^{weimingzhu@ouc.edu.cn"" rel=""nofollow}
• 关键词：Coral-associated fungus ; Cyclopentapeptides ; Polyketides ; Aspergillus versicolor ; Cladiella sp.
• 刊名：Tetrahedron
• 出版年：2011
• 出版时间：16 September 2011
• 年：2011
• 卷：67
• 期：37
• 页码：7085-7089
• 全文大小：354 K

文摘

Three new cyclopentapeptides, versicoloritides A–C (1–3), a new orcinol tetramer, tetraorcinol A (4), and two new lactones, versicolactones A and B (5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1–4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC₅₀ value of 67 μM.