An efficient one-pot method for the synthesis of novel ferrocene–triamide conjugates via pseudo five-component reaction

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• 作者：Mohammad Bagher Teimouri ; ^a ; ^{m.teimouri@ippi.ac.ir"" rel=""nofollow} ; Peyman Akbari-Moghaddam^a
• 关键词：Ferrocene– ; amide conjugate ; Isocyanide ; Meldrum’ ; s acid ; Multicomponent reaction
• 刊名：Tetrahedron
• 出版年：2011
• 出版时间：19 August 2011
• 年：2011
• 卷：67
• 期：33
• 页码：5928-5934
• 全文大小：759 K

文摘

A simple and efficient one-pot synthesis of novel ferrocene–triamide conjugates from the reaction of ferrocenecarboxaldehyde with Meldrum’s acid and isocyanides in the presence of NH-containing compounds is described. This transformation proceeds through the creation of two CC bonds, two CN bonds, and one CO bond, leading to three peptide bonds, and presumably occurs via a domino sequence involving Knoevenagel condensation, [1+4] cycloaddition, deacetonation, and aminolysis reactions.