Tension promoted circular probe for highly selective microRNA detection and imaging
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- 作者：Yaqin Tang ; Tingting Wang ; Ming Chen ; Xiao He ; Xiaohuan Qu ; Xuli Feng ; fengxuli@cqu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ring structure ; Tension ; Copper free click ; Strand displacement ; MicroRNA
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：151-156
- 全文大小：2157 K
文摘
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Locked circular DNA structure was formed based on copper free cycloaddition.
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Sealed circular DNA probe showed highly selective and sensitive DNA and miRNA detection at room temperature by simply mixing.
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The circular probe could even distinguish different site of single base mismatch.
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The circular probe achieved endogenous miR21 imaging in live cells based on “turn on” recovery of fluorescence.
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