Lysosomal ATP imaging in living cells by a water-soluble cationic polythiophene derivative
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- 作者：Bing-Huan Huang ; Zhi-Rong Geng ; gengzr@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiao-Yan Ma ; Cui Zhang ; Zhi-Yang Zhang ; Zhi-Lin Wang ; wangzl@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATP ; Detection ; Lysosome ; Water-soluble cationic polythiophene derivative ; Fluorescence imaging
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：213-220
- 全文大小：3570 K
文摘
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PEMTEI is the first fluorescent probe for the detection of ATP in lysosome.
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PEMTEI exhibits high selectivity and sensitivity to ATP in physiological conditions.
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PEMTEI has low cytotoxicity, good permeability and high photostability in cells.
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Lysosomes in HeLa cells can release ATP through Ca2+-dependent exocytosis.
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