Application of ethyl cellulose, microcrystalline cellulose and octadecanol for wax based floating solid dispersion pellets
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- 作者：Hong-Xiang Yan ytzjzyc@163.com" class="auth_mail" title="E-mail the corresponding author ; Shuang-Shuang Zhang ; Jian-Hua He ; Jian-Ping Liu ; liujianpingljp@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protocatechuic acid (PubChem CID ; 72) ; Octadecanol (PubChem CID ; 8821) ; Hexadecanol (PubChem CID ; 2682) ; Stearic acid (PubChem CID ; 5281) ; Glyceryl monostearate (PubChem CID ; 24699) ; Ethyl cellulose (PubChem CID ; 24832091) ; Microcrystalline cellulose (PubChem CID ; 14055602) ; Polyvinyl pyrrolidone (PubChem CID ; 6917) ; Ethanol (PubChem CID ; 702) ; Hydrochloric acid (PubChem CID ; 313)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：5 September 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：143-152
- 全文大小：2048 K
文摘
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Wax based floating solid dispersion pellets were developed and optimized.
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Low-density matrix pellet cores were prepared with the floating assistant octadecanol and microcrystalline cellulose.
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The fourth generation drug/ethyl cellulose dispersion was obtained and layered by single-step technique.
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Ethyl cellulose of various viscosities (10cp/45cp/100cp) has different sustained release abilities.
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SEM, DSC, XRD and FTIR were applied for physicochemical characterization.
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