The enhancement of bone regeneration by a combination of osteoconductivity and osteostimulation using ¦Â-CaSiO₃/¦Â-Ca₃(PO₄)₂ composite bioceramics

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• 作者：Chen  ; Wang^a ; Yang  ; Xue^a ; Kaili  ; Lin^b ; Jianxi  ; Lu^c ; Jiang  ; Chang^b ;   ; ^{jchang@mail.sic.ac.cn} ; Jiao  ; Sun^a ;   ; ^{jiaosun59@yahoo.com}
• 关键词：Calcium silicate ; Tricalcium phosphate ; Bioceramic ; Composites
• 刊名：Acta Biomaterialia
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：8
• 期：1
• 页码：350-360
• 全文大小：3784 K

文摘

¦Â-Tricalcium phosphate (¦Â-TCP) is osteoconductive, while ¦Â-calcium silicate (¦Â-CS) is bioactive with osteostimulative properties. Porous ¦Â-CaSiO_lns="""">3/¦Â-Ca_lns="""">3(PO_lns="""">4)_lns="""">2 composite bioceramic scaffolds with various ¦Â-TCP:¦Â-CS ratios were designed to combine both osteoconductivity and osteostimulation in order to enhance bone regeneration. The composite scaffolds were implanted in critical sized femur defects (6 ¡Á 12 mm) for 4, 12 and 26 weeks with pure ¦Â-TCP and ¦Â-CS scaffolds as the controls. The in vivo biodegradation and bone regeneration of the specimens were investigated using sequential histological evaluations, immunohistochemical examination and micro-computed tomography technology. The results showed that the scaffolds with 50 and 80 wt. % ¦Â-CS dramatically enhanced the amount of newly formed bone and reduced the degradation rate. In contrast, porous ¦Â-CS displayed poor new bone formation due to its rapid degradation, while porous ¦Â-TCP showed moderate bone regeneration starting on the surface of the implants, due to a lack of osteostimulation. More importantly, the scaffolds with 50 and 80 wt. % ¦Â-CS not only had excellent osteoconductivity, but also stimulated rapid bone formation, and they could degrade progressively at a rate matching the regeneration of new bone. In summary, our findings indicated that the degradation rate and bioactivity of ¦Â-CS/¦Â-TCP composite bioceramic scaffolds could be adjusted by controlling the ratio of ¦Â-CS to ¦Â-TCP, suggesting the potential application of ¦Â-CS/¦Â-TCP composite bioceramic scaffolds with 50 and 80 wt. % ¦Â-CS component in hard tissue regeneration and bone tissue engineering.