Ionic liquid-containing buffer system was first applied in the enzymatic synthesis of sucrose 6-acetate.

The [Dmim][PF6]–phosphate buffer system was identified as the optimum medium for the AoFT-catalyzed production of sucrose 6-acetate.

The highest glucose 6-acetate conversion and sucrose 6-acetate yield in the [Dmim][PF6]–buffer system were 88.2% and 77.2%, respectively.