Association of growth and nutritional parameters with pulmonary function in cystic fibrosis: a literature review

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• 作者：Renan Marrichi Mauch ; ^{renanmauch@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Arthur Henrique Pezzo Kmit ; Fernando Augusto de Lima Marson ; Carlos Emilio Levy ; Antonio de Azevedo Barros-Filho ; José ; Dirceu Ribeiro
• 关键词：Cystic fibrosis ; Lung/pathophysiology ; Growth ; Nutrition
• 刊名：Revista Paulista de Pediatria (English Edition)
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：34
• 期：4
• 页码：503-509
• 全文大小：591 K

文摘

To review the literature addressing the relationship of growth and nutritional parameters with pulmonary function in pediatric patients with cystic fibrosis.

Data source

A collection of articles published in the last 15 years in English, Portuguese and Spanish was made by research in electronic databases – PubMed, Cochrane, Medline, Lilacs and Scielo – using the keywords cystic fibrosis, growth, nutrition, pulmonary function in varied combinations. Articles that addressed the long term association of growth and nutritional parameters, with an emphasis on growth, with pulmonary disease in cystic fibrosis, were included, and we excluded those that addressing only the relationship between nutritional parameters and cystic fibrosis and those in which the aim was to describe the disease.

Data synthesis

Seven studies were included, with a total of 12,455 patients. Six studies reported relationship between growth parameters and lung function, including one study addressing the association of growth parameters, solely, with lung function, and all the seven studies reported relationship between nutritional parameters and lung function.

Conclusions

The review suggests that the severity of the lung disease, determined by spirometry, is associated with body growth and nutritional status in cystic fibrosis. Thus, the intervention in these parameters can lead to the better prognosis and life expectancy for cystic fibrosis patients.