MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome
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- 作者：Vaia Stavropoulou1 ; Susanne Kaspar2 ; 3 ; Laurent Brault1 ; Mathijs A. Sanders4 ; Sabine Juge1 ; Stefano Morettini2 ; Alexandar Tzankov5 ; Michelina Iacovino6 ; I-Jun Lau7 ; Thomas A. Milne7 ; Hé ; lè ; ne Royo2 ; Michael Kyba8 ; Peter J.M. Valk4 ; Antoine H.F.M. Peters2 ; 3 ; 9 ; antoine.peters@fmi.ch" class="auth_mail" title="E-mail the corresponding author ; Juerg Schwaller1 ; 9 ; j.schwaller@unibas.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：acute myeloid leukemia ; MLL-AF9 ; stem cell ; invasion ; EMT ; poor overall survival
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：11 July 2016
- 年：2016
- 卷：30
- 期：1
- 页码：43-58
- 全文大小：7033 K
文摘
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Generation of an inducible and reversible mouse model for MLL-AF9-driven AML
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The cell of origin controls aggressiveness and outcome of MLL-AF9-mediated AML
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The EMT transcription factor ZEB1 controls AML cell migration and invasion
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Expression of multiple EMT-related genes is associated with poor outcome in human AML
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