270 Increased hospital mortality in HIV-infected patients with acute coronary or cerebrovascular syndromes. Analysis from a French nationwide hospital medical information database

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• 作者：Luc Lorgis¹ ; Eric Benzenine² ; Yannick Bejot³ ; Marianne Zeller¹ ; Maurice Giroud³ ; Yves Cottin¹ ; Catherine Quantin²
• 刊名：Archives of Cardiovascular Diseases Supplements
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：3
• 期：1
• 页码：89
• 全文大小：51 K

文摘

Background

After more than two decades of the AIDS epidemic, the spectrum of HIV-associated vascular diseases has considerably evolved from infectious disease with improved survival, to premature atherosclerosis. As a consequence, acute atherosclerosis complications, such as acute coronary and cerebrovascular syndromes (ACS and CVS) are currently growing. However, only few data are available on HIV-infected patients in the setting of ACS/CVS. The aim of the present study was to determine the prevalence of HIV, as well as the characteristics and hospital case fatality of HIV-infected patients with CVS and ACS.

Methods

From the French nationwide hospital medical information database, data from all the consecutive patients hospitalized in the 1546 French hospital/clinics for CVS and/or ACS from 1^st January 2005 to 31^st December 2008 were analysed.

Findings

Among the 1.189,043 patients included, the prevalence of HIV infection was similar in CVS (0.21 % ) and ACS (0.19) patients (p = 0.0897). HIV patients were younger, and more frequently male.

When compared to HIV-uninfected patients, case fatality was markedly increased in HIV-infected patients after either CVS (OR (95 % CI): 1.73(1.45?.06)) or ACS (OR (95 % CI): 1.37(1.01?.86)), even after adjustment for sex and age or sex, age, and STEMI, respectively.

Conclusion

	HIV-uninfected n = 1161124	HIV Infected n = 2356	P
CVS	636728 (99.79 % )	1333 (0.21 % )	<0.0001
Age (years, mean ¡À SD)	72.4 ¡À 14.9	49.5 ¡À 12.0	<0.0001
Men	50.0 %	73.1 %	<0.0001
Case fatality	12.2 %	11.1 %	=0.2351
ACS	524396(99.81 % )	1023(0.19 % )	<0.0001
Age (years, mean ¡À SD)	68.9 ¡À 14.1	51.7 ¡À 10.7	<0.0001
Men	65.4 %	89.3 %	<0.0001
STEMI	42.9 %	57.6 %	<0.0001
Case fatality	6.6 %	4.4 %	=0.0041