A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans
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- 作者：Yang Li1 ; 8 ; 9 ; y.li01@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Marije Oosting2 ; 8 ; Sanne P. Smeekens2 ; 8 ; Martin Jaeger2 ; 8 ; Raul Aguirre-Gamboa1 ; Kieu T.T. Le1 ; Patrick Deelen1 ; 3 ; Isis Ricañ ; o-Ponce1 ; Teske Schoffelen2 ; Anne F.M. Jansen2 ; Morris A. Swertz1 ; 3 ; Sebo Withoff1 ; Esther van de Vosse4 ; Marcel van Deuren2 ; Frank van de Veerdonk2 ; Alexandra Zhernakova1 ; Jos W.M. van der Meer2 ; Ramnik J. Xavier5 ; 6 ; Lude Franke1 ; Leo A.B. Joosten2 ; leo.joosten@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author ; Cisca Wijmenga1 ; 7 ; c.wijmenga@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Vinod Kumar1 ; v.kumar@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Mihai G. Netea2 ; mihai.netea@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：cytokine QTL ; cytokine heritability ; innate immune response ; immunogenomics
- 刊名：Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：167
- 期：4
- 页码：1099-1110.e14
- 全文大小：6047 K
文摘
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Host genetics play a major role in inter-individual variability in cytokine responses
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Identification of 17 novel genome-wide significant cytokine QTLs (cQTLs)
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cQTLs generally overlap with genomic regions under positive selection
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Many cQTLs overlap with loci associated with infectious and immune-mediated diseases
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