BTLA⁺ Dendritic Cells: The Regulatory T Cell Force Awakens

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• 作者：Thomas Simon¹ ; ² ; Jonathan S. Bromberg¹ ; ² ; ³ ; ⁴ ; ^{jbromberg@smail.umaryland.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Immunity
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：45
• 期：5
• 页码：956-958
• 全文大小：402 K

文摘

The role of dendritic cells (DCs) in the induction of antigen-specific tolerance mediated by extrathymic regulatory T (Treg) cells remains incompletely defined. In this issue of Immunity, Jones et al. (2016) show that BTLA⁺DEC205⁺CD8⁺CD11c⁺ DCs efficiently induce peripheral Treg cells via the engagement of HVEM, a receptor for BTLA.