Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential
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- 作者：Wen-Lian Chen1 ; 2 ; 3 ; 5 ; Yue-Ying Wang1 ; 5 ; Aihua Zhao2 ; 5 ; Li Xia1 ; Guoxiang Xie2 ; 3 ; Mingming Su2 ; 3 ; Linjing Zhao3 ; Jiajian Liu2 ; Chun Qu2 ; Runmin Wei3 ; Cynthia Rajani3 ; Yan Ni2 ; 3 ; Zhen Cheng4 ; Zhu Chen1 ; Sai-Juan Chen1 ; sjchen@stn.sh.cn" class="auth_mail" title="E-mail the corresponding author ; Wei Jia2 ; 3 ; 6 ; wjia@cc.hawaii.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：fructose utilization ; acute myeloid leukemia ; SLC2A5 ; GLUT5
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：14 November 2016
- 年：2016
- 卷：30
- 期：5
- 页码：779-791
- 全文大小：4822 K
文摘
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AML cells are prone to fructose utilization to offset glucose insufficiency
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Increased SLC2A5 transcription and fructose utilization predict poor patient outcomes
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Enhanced fructose utilization exacerbates leukemic cell phenotypes
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Inhibition of fructose uptake shows therapeutic potential for AML
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