On-line monitoring system for chemical warfare agents using automated capillary micellar electrokinetic chromatography

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• 作者：Victoria V ; erNoot ; Scott Ferko ; James Van De Vreugde ; Kamlesh Patel ; Joanne Volponi ; Kevin Morrissey ; Lucille Forrest ; James Horton ; Brent Haroldsen
• 关键词：Micellar electrokinetic chromatography ; Chemical warfare agent ; Sulfur mustard ; Lewisite ; On-line monitoring ; Explosive destructive system
• 刊名：Journal of Chromatography A
• 出版年：2012
• 出版时间：3 August, 2012
• 年：2012
• 卷：1249
• 期：Complete
• 页码：233-240
• 全文大小：655 K

文摘

We present an automated analysis system for the detection of the chemical warfare blister agents, sulfur mustard (HD) and lewisite (L), in aqueous samples without any chemical derivatization. The system is compact in size and designed to operate in the field in a safe, autonomous manner for near real-time monitoring applications. It uses anionic surfactant-based capillary micellar electrokinetic chromatography (MEKC) to separate the sample followed by UV detection. The analysis time is sufficiently fast to allow direct detection of HD which enabled the estimation of effective hydrolysis rates in the aqueous sample matrix. The estimated hydrolysis half-life of HD in our system was 4.85 ¡À 0.05 min. The detection limit of HD was determined to be 10 ppm with a signal to noise ratio of 5. By contrast, L hydrolyzed too rapidly in aqueous samples to enable direct detection. Instead the first hydrolysis product 2-chlorovinyl arsonous acid (CVAA), also considered a blister agent, was detected with a detection limit of 0.7 ppm with a signal to noise ratio of 5.