Early bone mineral density decrease is associated with FSH and LH, not estrogen

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• 作者：Xi-Yu Wu^a ; Shan-Jiang Yu^b ; Hong Zhang^a ; Hui Xie^a ; Xiang-Hang Luo^a ; Yi-Qun Peng^a ; Ling-Qing Yuan^a ; Ru-Chun Dai^a ; Zhi-Feng Sheng^a ; Shi-Ping Liu^a ; Xian-Ping Wu^a ; ^{wuxiyu640@sohu.com} ; Er-Yuan Liao^a ;
• 关键词：Estradiol ; Follicle-stimulating hormone ; Luteinizing hormone ; BMD decreasing ; Native Chinese women
• 刊名：Clinica Chimica Acta
• 出版年：2013
• 出版时间：16 January, 2013
• 年：2013
• 卷：415
• 期：Complete
• 页码：69-73
• 全文大小：718 K

文摘

Background

It remains unclear whether gonadotropins or estrogen is responsible for early bone mineral density (BMD) decrease in Chinese women.

Methods

A cross-sectional study was conducted on 368 healthy adult women, aged 35-60 years. We measured BMD, calculated BMD decrease rates (BDRs) and assessed serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E₂) levels.

Results

BDR was significantly negatively correlated with serum FSH (r = ? 0.429 to ? 0.622, all p = 0.000) and LH (r = ? 0.359 to ? 0.526, all p = 0.000). After adjustment for age and body mass index, the negative correlations of serum FSH and LH with BDR persisted, but there was no overall correlation between serum E₂ and BDR. Multiple linear stepwise regression analysis suggested that serum FSH is a negative determinant of BDR. Serum E₂ seems to be a positive determinant of BDR in a few parts of the skeleton.

Conclusions

The decrease of BMD during the menopause is associated with FSH and LH levels, rather than E₂ in Chinese women.