gga-miR-2127 downregulates the translation of chicken p53 and attenuates chp53-mediated innate immune response against IBDV infection

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• 作者：Wei Ouyang^a ; ^b ; ^c ; ^d ; Yong-shan Wang^a ; ^b ; ^{wangys63@126.com} ; Kai Meng^a ; ^b ; Qun-xing Pan^a ; ^b ; Xiao-li Wang^a ; ^b ; Xing-xia Xia^a ; ^b ; Yu-mei Zhu^a ; ^b ; Zhen-wei Bi^a ; ^b ; Hai-bin Zhang^d ; Kai Luo^c ; ^{nanjingluokai@hotmail.com}
• 关键词：Infectious bursal disease ; chp53 ; miRNA ; gga-miR-2127 ; Antiviral innate immunity
• 刊名：Veterinary Microbiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：198
• 期：Complete
• 页码：34-42
• 全文大小：1009 K
• 卷排序：198

文摘

IBDV infection could increase the activity of chicken p53. Chicken p53 severing as an antiviral factor against IBDV in chicken. gga-miR-2127 can directly target on chicken p53 3' UTR and is a negative regulator of chicken p53.