Identification of sea perch (Lateolabrax japonicus) ribonucleoprotein PTB-Binding 1 involved in antiviral immune response against RGNNV

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• 作者：Peng Jia¹ ; ^{jiapeng19890219@126.com} ; Wei Liu¹ ; ^{liuw68@mail.sysu.edu.cn} ; Limin Chen ^{2562492896@qq.com} ; Yilin Jin ^{369277368@qq.com} ; Jing Zhang ^{zhangj358@mail.sysu.edu.cn} ; Kuntong Jia ; ^{jiakuntong@126.com} ; Meisheng Yi ; ^{yimsh@mail.sysu.edu.cn}
• 关键词：Ribonucleoprotein PTB-Binding 1 ; Sea perch ; Redspotted grouper nervous necrosis virus ; RIG-I-like receptors ; Innate immune
• 刊名：Fish & Shellfish Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：119-128
• 全文大小：3202 K
• 卷排序：60

文摘

The Raver1 was identified from sea perch for the first time. LjRAVER1 transcripts were induced greatly post RGNNV infection in vivo. LjRAVER1 was involved in response to poly(I:C) and RGNNV stimulation in vitro. Overexpression of LjRAVER1 inhibited the replication of RGNNV. The ectopic expression of LjRAVER1 activated RLR signaling pathway.