Identification and functional characterization of a novel Spätzle gene in Litopenaeus vannamei

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• 作者：Kai Yuan^b ; ^c ; Feng-Hua Yuan^b ; ^c ; Shao-Ping Weng^b ; ^c ; Jian-Guo He^a ; ^b ; ^c ; Yi-Hong Chen^a ; ^c ; ^{chenyh6@mail.sysu.edu.cn}
• 关键词：Toll-like receptor ; NF-κB ; Sp&auml ; tzle ; Unfolded protein response ; Litopenaeus vannamei ; Vibrio alginolyticus
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：68
• 期：Complete
• 页码：46-57
• 全文大小：3945 K
• 卷排序：68

文摘

Cloned a novel Spätzle gene (LvSpz4) in Litopenaeus vannamei. Spaetzle domain of LvSpz4 activated the promoter of antibacterial peptide genes and WSSV ie1 gene in S2 cells. LvSpz4 was upregulated by Vibrio alginolyticus-, Staphylococcus aureus infection or lipopolysaccharide stimulation. Knocked-down expression of LvSpz4 caused a higher cumulative mortality upon V. alginolyticus infection for L. vanname. LvSpz4 was induced by unfolded protein response (UPR) in L. vannamei.