Generation and characterization of new monoclonal antibodies against swine origin 2009 influenza A (H1N1) virus and evaluation of their prophylactic and therapeutic efficacy in a mouse model

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• 作者：Sheng-Fan Wang^a ; ^b ; ^{wasf1234@kmu.edu.tw} ; Sung-Pin Tseng^a ; El-Wui Loh^c ; Wen-Hung Wang^d ; Ming-Chun Li^e ; Kuan-Hsuan Chen^b ; Wan-Chi Tsai^a ; Yuan-Ming Lee^f ; Huan-Yuan Chen^g ; ^h ; Fu-Tong Liu^g ; ^h ; Yi-Ming Arthur Chen^b ; ⁱ ; ^{arthur@kmu.edu.tw} ; Jason C. Huang^j ; ^k ; ^{jchuang2@ym.edu.tw}
• 关键词：H1N1 ; Influenza virus ; Monoclonal antibody ; Trimeric hemagglutinin ; Epitope ; Prophylactic ; Therapeutic
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：8-17
• 全文大小：3044 K
• 卷排序：67

文摘

Trimeric recombinant hemagglutinin glycoprotein is a good immunogen for production of neutralizing Abs. Our generated monoclonal antibodies(mAbs) recognize two new protective and neutralizing epitopes on HA globular head. The generated mAbs reduce both mice death rate and proinflammatory cytokines. The generated mAbs display therapeutic and prophylactic effects as well as synergistic efficacy with Oseltamivir.