Molecular and functional characterization of pigeon (Columba livia) tumor necrosis factor receptor-associated factor 3

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• 作者：Yingying Zhou ; Xilong Kang ; Dan Xiong ; Shanshan Zhu ; Huijuan Zheng ; Ying Xu ; Yaxin Guo ; Zhiming Pan ; ^{zmpan@yzu.edu.cn} ; Xinan Jiao ; ^{xajiao@yzu.edu.cn}
• 关键词：Pigeon ; Tumor necrosis factor receptor-associated factor 3 ; Cloning ; Function ; Identification
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：69
• 期：Complete
• 页码：51-59
• 全文大小：2565 K
• 卷排序：69

文摘

Pigeon TRAF3 was expressed in all tested tissues. The MATH domain is necessary for IFN-β promoter activation. The zinc finger and coiled coil are essential for NF-κB activation. R848 induces TRAF3 and cytokine up-regulation in pigeon PBMCs and splenocytes.