Response surface-optimized preparation of anthocyanin-loaded chitosan nanoparticles. Box-Behnken design for high encapsulation efficiency and small particle size. First anthocyanin nanoparticles of carboxymethyl chitosan and chitosan hydrochloride. Chitosan nanoparticles delayed anthocyanin degradation in simulated GI fluid. Chitosan nanoparticles increased anthocyanin storage stability in a model beverage.