Fabrication of selenium-deposited and chitosan-coated titania nanotubes with anticancer and antibacterial properties

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• 作者：Xiuyong Chen ; Kaiyong Cai ; ^{kaiyong_cai@cqu.edu.cn} ; Jiajia Fang ; Min Lai ; Yanhua Hou ; Jinghua Li ; Zhong Luo ; Yan Hu ; Liling Tang
• 关键词：TiO2 nanotubes ; Selenium deposition ; Chitosan ; Anticancer property ; Antibacterial property
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2013
• 出版时间：1 March, 2013
• 年：2013
• 卷：103
• 期：Complete
• 页码：149-157
• 全文大小：1309 K

文摘

To exploit titanium materials with anticancer and antibacterial properties, TiO₂ nanotubes arrays as nanoreservoirs for deposition of selenium were generated onto titanium substrates and then covered with chitosan layer. The deposition of selenium in TiO₂ nanotubes was performed with electrodeposition. The physical properties (surface morphologies, chemical compositions and wettability) of the substrates were characterized by field-emission scanning electron microscopy (FE-SEM) equipped with energy dispersive X-ray spectroscopy (EDS) and contact angle measurement, respectively. The growth behaviors of both healthy osteoblasts and cancerous osteoblasts on the substrates were investigated in vitro. The selenium-deposited and chitosan-coated TiO₂ nanotubes substrates (TiO₂ nanotubes-Se-Chi) demonstrated great potential for promoting the proliferation of healthy osteoblasts and inhibiting the growth of cancerous osteoblasts. Meanwhile, the TiO₂ nanotubes-Se-Chi substrates displayed a sustained release of selenium for 21 days. The antibacterial properties of the prepared substrates were evaluated with Escherichia coli (E. coli). The result showed that TiO₂ nanotubes-Se-Chi substrates had long term antibacterial capacity. The approach in this study provides an alternative to fabricate anticancer and antibacterial titanium-based implants for potential clinical application.