Antioxidant, antibacterial and anti-aging activities of intracellular zinc polysaccharides from Grifola frondosa SH-05

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• 作者：Chen Zhang^a ; ^b ; ¹ ; Zheng Gao^b ; ¹ ; Chunlong Hu^c ; ¹ ; Jianjun Zhang^b ; Xinyi Sun^b ; Chengbo Rong^a ; ^{woshiboer@163.com} ; Le Jia^b ; ^{jiale0525@163.com}
• 关键词：Ara ; arabinose ; BHI ; brain heart infusion ; DG ; dentate gyrus ; DPPH ; 1 ; 1-diphenyl-2-picrylhydrazyl ; FAAS ; flame atomic absorption spectrometry ; GC ; gas chromatography ; Glu ; glucose ; Gal ; galactose ; HE ; hematoxylin-eosin ; IZPS ; intracellular zinc polysaccharides ; IPS ; intracellular polysaccharides ; Ino ; inositol ; MDA ; malondialdehyde ; Man ; mannose ; MIC ; minimal inhibitory concentration ; PDA ; potato dextrose agar ; ROS ; reactive oxygen species ; Rha ; rhamnose ; Rib ; ribose ; SOD ; superoxide dismutase
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：778-787
• 全文大小：3388 K
• 卷排序：95

文摘

In present work, the strain of Grifola frondosa SH-05 was used as a vector of zinc biotransformation to produce the IZPS. The bioactivities including antioxidant and antibacterial activities in vitro and anti-aging properties in vivo of IZPS were investigated comparing with the IPS. The results which were in consistent with the results of histopathology assay demonstrated that the IZPS had superior antioxidant and anti-aging activities by scavenging the hydroxyl and DPPH radicals, increasing enzyme activities, decreasing the MDA contents and ameliorating the anile condition of mice. Besides, the IZPS also showed potential antibacterial activities. The IZPS with higher bioactivities was composed of were Rha, Ino and Glu with a molar ratio of 4.7:3.6:1. These conclusions indicated that the IZPS might be a potential source of natural antioxidant, antibacterial agent and anti-aging agent.