Down-regulation of fibroblast growth factor 2 and its co-receptors heparan sulfate proteoglycans by resveratrol underlies the improvement of cardiac dysfunction in experimental diabetes

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• 作者：Cé ; lia Maria Cá ; ssaro Strunz ; ^{labcelia@incor.usp.br} ; Alessandra Roggerio ^{alessandra.roggerio@incor.usp.br} ; Paula Lá ; zara Cruz ^{paulalcruz@gmail.com} ; Ana Paula Pacanaro ^{ana.pacanaro@incor.usp.br} ; Vera Maria Cury Salemi ^{verasalemi@uol.com.br} ; Luiz Alberto Benvenuti ^{benvenutianpluiz@incor.usp.br} ; Antonio de Pá ; dua Mansur ^{antonio.mansur@incor.usp.br} ; Maria Clá ; udia Irigoyen ^{maria.irigoyen@incor.usp.br}
• 关键词：A ; Late diastolic mitral inflow ; A&rsquo ; late diastolic peak velocity ; AMPK ; AMP-activated protein kinase ; BMI ; Body mass index ; E ; Early diastolic mitral inflow ; E&rsquo ; early diastolic peak velocity ; FGF ; Fibroblast Growth Factor ; GAPDH ; Glyceraldehyde 3-phosphate dehydrogenase ; HSPGs ; Heparan sulfate proteoglycans ; IVRT ; Isovolumic relaxation time ; LV ; Left ventricular ; N-A ; Naso-anal length ; PPARα ; Peroxisome proliferator-activated receptor alpha ; PPARγ ; Peroxisome proliferator-activated
• 刊名：The Journal of Nutritional Biochemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：40
• 期：Complete
• 页码：219-227
• 全文大小：1040 K
• 卷排序：40

文摘

Cardiac remodeling in diabetes involves cardiac hypertrophy and fibrosis, and fibroblast growth factor 2 (FGF2) is an important mediator of this process. Resveratrol, a polyphenolic antioxidant, reportedly promotes the improvement of cardiac dysfunction in diabetic rats. However, little information exists linking the amelioration of the cardiac function promoted by resveratrol and the expression of FGF2 and its co-receptors, heparan sulfate proteoglycans (HSPGs: Glypican-1 and Syndecan-4), in cardiac muscle of Type 2 diabetic rats. Diabetes was induced experimentally by the injection of streptozotocin and nicotinamide, and the rats were treated with resveratrol for 6 weeks. According to our results, there is an up-regulation of the expression of genes and/or proteins of Glypican-1, Syndecan-4, FGF2, peroxisome proliferator-activated receptor gamma and AMP-activated protein kinase in diabetic rats. On the other hand, resveratrol treatment promoted the attenuation of left ventricular diastolic dysfunction and the down-regulation of the expression of all proteins under study. The trigger for the changes in gene expression and protein synthesis promoted by resveratrol was the presence of diabetes. The negative modulation conducted by resveratrol on FGF2 and HSPGs expression, which are involved in cardiac remodeling, underlies the amelioration of cardiac function.