Msx1-Positive Progenitors in the Retinal Ciliary Margin Give Rise to Both Neural and Non-neural Progenies in Mammals

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• 作者：Marie-Claude Bé ; langer¹ ; ² ; Benoit Robert³ ; Michel Cayouette¹ ; ² ; ⁴ ; ⁵ ; ^{michel.cayouette@ircm.qc.ca}
• 关键词：retina ; ciliary margin ; lineage ; fate decision ; mouse genetics ; conditional knockout ; Numb ; neurogenesis ; Msx1 ; stem cell
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：40
• 期：2
• 页码：137-150
• 全文大小：5844 K
• 卷排序：40

文摘

Msx1 expression defines a proximal domain in the mouse ciliary margin zone Msx1-expressing progenitors give rise to neural retina and non-neural epithelia The Msx1-derived retinal progenies include all seven major retinal cell types Numb regulates the neural/non-neural fate decision in Msx1 progenitors