Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat

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• 作者：Gisela E. Pennacchio^a ; ^b ; ^{gpennacchio@mendoza-conicet.gov.ar} ; Flavia J. Neira^a ; Marta Soaje^a ; ^c ; Graciela A. Jahn^a ; Susana R. Valdez^a ; ^b ; ^{svaldez@mendoza-conicet.gov.ar}
• 关键词：Pregnancy ; Lactation ; Hyperthyroidism ; PRL ; Hypothalamic dopaminergic neurons ; Tyrosine hydroxylase ; PRL signaling pathway
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：442
• 期：Complete
• 页码：40-50
• 全文大小：1401 K
• 卷排序：442

文摘

HyperT blocks suckling-induced PRL release and advances the prepartum PRL surge. HyperT elevated hypothalamic TH mRNA and p-TH on late pregnancy and early lactation. PRLR, STAT5, CIS, PRA and B also increased on late pregnancy and/or early lactation. The altered PRL signaling and PRs may induce elevated TH expression and activation. This elevates dopaminergic tone on lactation, blunting PRL release and litter growth.