Unliganded estrogen receptor alpha regulates vascular cell function and gene expression

详细信息    查看全文

• 作者：Qing Lu^a ; Gavin R. Schnitzler^a ; ^{gschnitzler@tuftsmedicalcenter.org} ; Caroline S. Vallaster^a ; Kazutaka Ueda^a ; Stephanie Erdkamp^a ; Christine E. Briggs^b ; Lakshmanan K. Iyer^a ; Iris Z. Jaffe^a ; Richard H. Karas^a ; ^{richard.karas@gmail.com}
• 关键词：Estrogen receptor alpha ; Vascular injury ; Cell proliferation ; Gene regulation
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：442
• 期：Complete
• 页码：12-23
• 全文大小：1647 K
• 卷排序：442

文摘

Unliganded estrogen receptor alpha (ERα) has been thought to be largely inactive. We show that unliganded ERα has pathology-associated effects on vascular cells. Unliganded ERα regulates many genes in endothelial cells and in whole mouse aorta. Estradiol has opposing physiological effects and regulates distinct gene sets. Novel, actively harmful effects of unliganded ERα have important implications.