文摘
Metformin can inhibit adipogenesis through AMPK-dependent or -independent mechanisms, depending on the cellular context. Metformin suppresses adipogenesis in C3H10T1/2 mesenchymal stem cells (MSCs), independently of AMPK. Metformin exerts reciprocal control over osteogenic (Runx2) and adipogenic (PPARγ) transcription factors in MSCs. Basal AMPK and mTOR/p70S6K activity are required for adipogenesis in MSCs.