Proinsulin C-peptide modulates the expression of ERK1/2, type I collagen and RANKL in human osteoblast-like cells (Saos-2)

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• 作者：Cristina Russo^a ; Veronica Lazzaro^b ; Carmine Gazzaruso^c ; Samantha Maurotti^a ; Yvelise Ferro^a ; Piero Pingitore^d ; Francesca Fumo^a ; Adriana Coppola^c ; Pietro Gallotti^c ; Valentina Zambianchi^c ; Mariangela Fodaro^c ; Emanuela Galliera^e ; Monica Gioia Marazzi^f ; Massimiliano Marco Corsi Romanelli^f ; Sandro Giannini^g ; Stefano Romeo^a ; ^d ; Arturo Pujia^a ; Tiziana Montalcini^h ; ¹ ; ^{tmontalcini@unicz.it}
• 关键词：Proinsulin C-peptide ; Insulin ; Osteoporosis ; Type I collagen ; RANKL
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：442
• 期：Complete
• 页码：134-141
• 全文大小：1365 K
• 卷排序：442

文摘

In this study C-peptide activates the ERK1/2 signaling in Saos-2. C-peptide prevents the reduction of type I collagen mRNA and protein. Pro-insulin C-peptide decreases RANKL mRNA and protein levels. C-peptide might contribute to the reparative mechanisms of bone tissue.